GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs111803315 | 1 | rs112661971 | chr14:59901054 | JKAMP | chr14:59951161-59972080:+ | 0.31 | 5.36 | 1.04E-7 | Schizophrenia |
| BRCA | cis | rs1853207 | 1 | rs112732395 | chr10:96533173 | C10orf129 | chr10:96953957-96988685:+ | 0.32 | 5.36 | 1.03E-7 | Blood metabolite levels |
| BRCA | cis | rs7762018 | 1 | rs1127489 | chr6:170107702 | WDR27 | chr6:169857307-170102159:- | -0.12 | -3.47 | 0.000534 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| BRCA | cis | rs11758351 | 1 | rs112751982 | chr6:26191958 | HIST1H3E | chr6:26224427-26226589:+ | 0.35 | 6.81 | 1.61E-11 | Renal underexcretion gout;Gout |
| BRCA | cis | rs12468226 | 1 | rs112753638 | chr2:203199219 | NOP58 | chr2:203130515-203168382:+ | 0.15 | 3.41 | 0.000665 | Urate levels |
| BRCA | cis | rs867186 | 1 | rs112777695 | chr20:33693177 | MMP24 | chr20:33814539-33864804:+ | -0.19 | -3.44 | 0.000595 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs867186 | 1 | rs112777695 | chr20:33693177 | PROCR | chr20:33758727-33765164:+ | -0.23 | -4.8 | 1.81E-6 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs1853207 | 1 | rs112779036 | chr10:96498813 | C10orf129 | chr10:96953957-96988685:+ | 0.33 | 5.5 | 4.85E-8 | Blood metabolite levels |
| BRCA | cis | rs7104764 | 1 | rs1128320 | chr11:244167 | PSMD13 | chr11:236808-252984:+ | -0.16 | -4.58 | 5.13E-6 | Menarche (age at onset) |
| BRCA | cis | rs7104764 | 1 | rs1128322 | chr11:244197 | PSMD13 | chr11:236808-252984:+ | 0.16 | 4.4 | 1.2E-5 | Menarche (age at onset) |
| BRCA | cis | rs11190604 | 1 | rs11292 | chr10:102313607 | SEC31B | chr10:102246403-102289636:- | -0.27 | -10.05 | 9.35E-23 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs5756813 | 1 | rs1129448 | chr22:38170026 | TRIOBP | chr22:38082344-38172562:+ | 0.16 | 5.43 | 7.07E-8 | Optic cup area;Vertical cup-disc ratio |
| BRCA | cis | rs1049564 | 1 | rs1130650 | chr14:20940626 | PNP | chr14:20937542-20945246:+ | -0.17 | -4.26 | 2.23E-5 | Interferon alpha levels in systemic lupus erythematosus |
| BRCA | cis | rs1853207 | 1 | rs113089853 | chr10:96545632 | C10orf129 | chr10:96953957-96988685:+ | 0.32 | 5.36 | 1.03E-7 | Blood metabolite levels |
| BRCA | cis | rs1853207 | 1 | rs113103955 | chr10:96414633 | C10orf129 | chr10:96953957-96988685:+ | 0.33 | 5.32 | 1.25E-7 | Blood metabolite levels |